NSC 309132 - Names and Identifiers
NSC 309132 - Physico-chemical Properties
| Molecular Formula | C9H12N2O5
|
| Molar Mass | 228.2 |
| Density | 1.73±0.1 g/cm3(Predicted) |
| Melting Point | 160-162?C |
| Boling Point | 499.0±55.0 °C(Predicted) |
| Appearance | Form solid, color White |
| pKa | 13.48±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month. |
| Physical and Chemical Properties | Bioactive Zebularine (NSC 309132, 4-Deoxyuridine) is a DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases and also inhibits cytidine deaminase. Ki is 2 μM in cell-free test. |
NSC 309132 - Risk and Safety
| WGK Germany | 3 |
| RTECS | UW7539720 |
NSC 309132 - Introduction
4-Deoyuridine(4-Deoxyuridine) is a pyrimidine nucleoside with the chemical formula C9H12N2O5. It is a colourless solid and appears as a colorless transparent solution when dissolved in water.
4-Deoyuridine has important biological functions in organisms. It is one of the components of DNA and can provide pyrimidine bases for use in DNA synthesis. Therefore, it is mainly used in the laboratory to study and analyze the synthesis, repair and reorganization of DNA.
The preparation of 4-Deoyuridine can be achieved by chemical synthesis methods. A common method is based on Pyrimidine as the starting material, through a series of chemical reaction steps, such as substitution reaction and oxidation reaction, to obtain the final product.
When using 4-Deoyuridine, you need to pay attention to safety matters. It is a powder or crystal that may cause irritation to the eyes, skin and respiratory tract. During the operation, appropriate personal protective equipment should be worn, such as laboratory gloves, safety glasses and protective face masks. During handling and storage, avoid contact with oxidants, acids and high temperatures to avoid fire or explosion. If there is an accident, the contaminated area should be cleaned in time and medical help should be sought.
Last Update：2024-04-10 22:29:15